JamesAndrews.TV http://jamesandrews.tv My Life Is Content posterous.com Mon, 23 Jan 2012 04:46:32 -0800 Headed To Summit Series Basecamp--Here are memories of the last Summit at Sea http://jamesandrews.tv/headed-to-summit-series-basecamp-here-are-mem http://jamesandrews.tv/headed-to-summit-series-basecamp-here-are-mem
As I get ready to pack up and leave for Summit Series Basecamp I can't help but to reflect on the last Summit Series at Sea. Probably one of the best gatherings I have ever attended and well worth the time and money. Here's a great recap. To my Summiteers, see you in Squaw Valley

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Mon, 16 Jan 2012 05:23:00 -0800 MLK For Public Relations Professionals--A Must Watch For Those In PR/Media http://jamesandrews.tv/mlk-for-public-relations-professionals-a-must http://jamesandrews.tv/mlk-for-public-relations-professionals-a-must
I like many Americans am taking the day off today for a day of service in Atlanta, GA. Pretty amazing that I get to share an office in the exact neighborhood that Dr.  King lived; Not a day goes by that I don't think about him since I have to pass his home every time I go in.

If you are working in Public Relations or media I found this video today that is just for you. I have earmarked this for PR Pros in the instance you have to do media training and/or have a client with a tough interview or speech.

In this interview on the Mike Douglas Show, Dr. King brings a few very simple principles for media and messaging. In fact I recommend this as a "must watch" for your clients. Dr. King is simply one of the greatest orators and interviewers we have seen.

1. Be Prepared-Know your stuff.
2. Be Calm. Never be totally swayed by tough questions. Dr. King handles this situation with amazing grace.
3. Persuasion is amazing to watch. You can literally see them both becoming advocates
4. Steer the conversation towards your intended message points
5. Come in Love and Peace

Happy MLK Day.

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Tue, 03 Jan 2012 05:05:00 -0800 My Clean Program Health Decisions in 2011 Set Me Up For A Great 2012 http://jamesandrews.tv/my-clean-cleanprogram-health-decisions-in-201 http://jamesandrews.tv/my-clean-cleanprogram-health-decisions-in-201
Last year one of the highlights was getting my arms around removing toxins from my body through the use of Dr. Junger's Clean Program.
I participated in (2) Twenty-one day cleanses and felt AMAZING, had way more energy and though it was not my focus lost about 20lbs. 

Do I eat like this everyday??? NO. In fact truth be told I was the least of the candidates to be doing a cleanse. This made it all the more remarkable.
Clean Program was an amazing experience for me and I feel like I have a solid foundation to start 2012. I know how to "snap" back into clean eating when things slip. I recommend Clean Program to anyone! If I can do it, YOU CAN do it.

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Sun, 11 Dec 2011 20:03:58 -0800 Customer Service Is Why I'm In A Monogamous Relationship With @Delta Airlines http://jamesandrews.tv/customer-service-is-why-im-in-a-monogamous-re http://jamesandrews.tv/customer-service-is-why-im-in-a-monogamous-re

Living in Atlanta has its perks and being centrally located in the Delta Airlines hub is one of them. I fly a ton and 99% of my flights are on Delta Airlines. Honestly, I used to be really bad about frequent flyer programs and Delta became the first consistent relationship I built with an airline. I have to admit "membership has its benefits" and when you fly as much as I do an upgrade, priority bag handling or same day confirm can make a huge difference. I also doubled up and became a member of the Delta Sky Club which on more than a few occassions of being delayed has been a complete lifesaver (see LAX Two summers ago with wife and two kids--Yikes). Last year despite a couple of journeys to Europe I missed achieving diamond status by a short distance. This year, with a new Social People office in LA, clients in London, new business opportunities in Brazil and a visit to Paris for LeWeb I officially made diamond. As someone who helps Fortune 500 companies with developing social media customer service strategies I have to say that Delta does an AMAZING job of listening to consumers thru social media channels. If I send a tweet to @Delta I get very fast responses from @DeltaAssist and they have been amazing in some very tough situations. Delta is not a current client, I'm just a loyal customer and love to tell stories of the brands that do it right. Very classy move on their behalf in recognizing my diamond qualifying flight. As we were landing an attendant came to my seat with a bottle of wine and as we were landing I was congratulated on the PA. 

Diamondlife

 

Here's the Delta red coats waiting for me as I landed tonight from Paris. Getting to diamond means a lot of time away from my wife. Super excited that she happened to be on this flight with me.

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Sat, 10 Dec 2011 13:40:00 -0800 #LeWeb11 Made Me Become A Huge Karl Lagerfeld Fan http://jamesandrews.tv/leweb11-made-me-become-a-huge-karl-lagerfeld http://jamesandrews.tv/leweb11-made-me-become-a-huge-karl-lagerfeld

I already knew him as a fashion design innovator but the personal tour of his digital/mobile "game" turned me into a big fan. Paris loves Karl.

Karl

 

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Wed, 07 Dec 2011 15:42:00 -0800 I'm Featured On The Cover Of This Month's Atlanta Tastemaker Magazine (@TastemakerMag) http://jamesandrews.tv/im-featured-on-the-cover-of-this-months-atlan http://jamesandrews.tv/im-featured-on-the-cover-of-this-months-atlan
Media_httpimageissuuc_jzjbi

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Sun, 27 Nov 2011 17:49:49 -0800 It's A Marathon Not A Race: 7 Tips To Staying Married http://jamesandrews.tv/marriage-its-a-marathon-not-a-race http://jamesandrews.tv/marriage-its-a-marathon-not-a-race

Us
18yrritzcarlton
Today my wife Sherrelle and I are celebrating 18 years of marriage. Whoa! Where did the time go!! I know without a shadow of a doubt that marrying her was the single most important decision I have made in my life. Have we had problems you ask? Absolutely, our marriage has endured its share of ups and downs. Has it made us stronger? YES. I can say that at 18 years today we are a solid unit and work in total unison. Didn't say total agreement, I said "unison." I know that my approach and look at things is totally different at times than my wife's. It is operating in this difference and respecting each other's unique perspective that help us make wise family decisions. One thing that we are completely on the same page about is the fact that without a spiritual relationship our marriage means nothing. We give Jesus Christ the glory, honor and praise for guiding us daily. This "relationship" is more than just attending church but it's about a filter in which we view life's challenges on a daily basis--and there are SO MANY daily challenges to filter.

As an entrepreneur my wife is an "investor" in my company by providing the backbone support for the family. There is ABSOLUTELY no way that I would be able to run a successful business, manage employees and maintain two offices if Sherrelle wasn't operating as COO of the Andrews Family. That trust I have in her managing the details which include but are in no way limited to: Paying the bills, planning vacations, managing the school calendar, researching things for us to do on weekends, and so on, and so on, and on. My wife's ability to organize all the other functions of my life allow me to focus on running the company and simply having the room to create visions and for that she is a huge investor in my company. I cherish the role she plays and really travel when I have to and when in town do my best to support her role. Lastly, my wife is my emotional cheerleader and confidant. It is here where I need and depend on her so much. The way I look at life, business, friends, family can be so out of wack that without my wife giving me a proper grounding and sometimes additional viewpoint I would completely make several "bonehead decisions." I confer with Sherrelle on so many decisions and trust her intution. I know and respect a "woman's intuition" and my wife has the best "Spidey Sense" in the business.

Some of you reading this may not be married yet and considering marriage one day. Maybe you have been married in the past, it ended badly and you are tainted by the whole experience. Perhaps you are in a marriage and are trying to figure out how to get out. Whatever your situation I have this to say to you: Marriage is A MARATHON, NOT A RACE. In plain speak it means that you have to CHOOSE to be married not expect some "oooeey goooey" feeling to take over your body on a daily basis. Our media obsessed culture has many of us totally confused on what real love looks like and most importantly what it takes to survive. So many men I know have a "jacked up" view of sex because of a lust filled culture and pornography. Lastly couples in general lack the commitment to sustainable marriages because of the popular "He/She is not making ME HAPPY" mentality that permeates the way we view marriage. By true confession I'm not a marriage counselor or trained therapist. However (and unfortunately) at 18 years of marriage I'm a member of this rare fraternity of people who make it past 7-10 years of marriage.Here are a few tips that might help you on your journey of marriage:

  • Fellas Take The Sword: This means at times (like 90%) you need to "fall on the sword" in an arugment for the sake of your marriage. I promise you this will save you a lot of heartache, time and pain. BE the peacemaker by being the bigger adult. Yes EVEN when she's dead wrong.
  • Eat Dinner At Home As A Family: I noticed that our marriage and relationship as a family changed for the better when we actually committed to a consistent family dinner time at the table. It may last 30 minutes but it is the best time to connect with your wife and family
  • Shut It Down: Try and turn off electronics and just soak up your wife. I am still working on this in true confession which tells you how long it actually takes. The fact that I work in Social Media and my wife is a blogger doesn't help. Try it I promise it works
  • Find A Shared Passion: My wife and I have recently realized we share a passion for health/fitness. Sherrelle has done a Clean Program Cleanse with me for 21 days and I most recently took up Kettlebells at her suggestion and we work out in the morning together
  • Snuggle Up: Every time you come to bed you don't have to hit a "home run." Practice the art of some good ol' Spoonin which in the end leads to even bigger fireworks.
  • Care About Things She Cares About: Guess what, life is not just about YOU. Get into her life and be bummed or be happy about the things that move her emotionally. Women are driven by the details of the day. Be authentically involved in her daily details
  • Wise Counsel: You need to keep a few men around you that have some wisdom and have been married several years. If your mentor's advice to you is "Go get you a chick on the side" RUN IMMEDIATELY and find a new mentor, he's not your guy homie!

There are so many tips that I could share but I just wanted to get this blog post off my chest. I hope that you find some of what I'm sharing helpful. As we celebrated our marriage today I felt so blessed and humbled that we have made it this far. DIVORCE IS NOT AN OPTION for us and we truly practice that. I would be nothing if I couldn't at least help a few marriages make it. It's really tough out there and I want nothing else but to see marriages survive. Again without God I would not even be able to write this post and celebrate this marriage. My best to you. Let me know what tips you have.

 

 

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Sat, 26 Nov 2011 16:40:20 -0800 "Rocking' Around The Christmas Tree" Is Tonight's Christmas Mood Catalyst http://jamesandrews.tv/rocking-around-the-christmas-tree-is-tonights http://jamesandrews.tv/rocking-around-the-christmas-tree-is-tonights
IMG_4161.MOV Watch on Posterous

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Thu, 24 Nov 2011 20:12:42 -0800 "Fast Food, Fat Profits-Obesity In America" Great Web Video by Al Jazeera (@AJFaultLines)--Happy Thanksgiving Ya'll http://jamesandrews.tv/fast-food-fat-profits-obesity-in-america-grea http://jamesandrews.tv/fast-food-fat-profits-obesity-in-america-grea Doing a little research on a future project and stumbled across this good video on obesity. I know it's Thanksgiving, don't be mad. Hope you ate some fresh vegetables today.




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Tue, 15 Nov 2011 20:10:27 -0800 Footage From #ShiftNYC Featuring Howard Lindzon (@howardlindzon) http://jamesandrews.tv/footage-from-shiftnyc-featuring-howard-lindzo http://jamesandrews.tv/footage-from-shiftnyc-featuring-howard-lindzo Another great video from Howard Lindzon on #ShiftNYC which one participant called the "Best Event of 2011"
Look for us to be in several more cities next year.
For more information go to Shift.PGI.com




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Tue, 15 Nov 2011 19:57:00 -0800 Great video From #ShiftNYC on Lane Wood (@lanewood) and Joe Huff (@joehuffLA) http://jamesandrews.tv/great-video-from-shiftnyc-on-lane-wood-lanewo http://jamesandrews.tv/great-video-from-shiftnyc-on-lane-wood-lanewo
In September Social People produced a conference called #ShiftNYC with our client iMeet.
We brought together the thought leaders in New York City to share visions of a future workspace, investment, broadcast, workspace/environment and social entrepreneurship. 
It was an amazing event as evidenced by everyone who attended.
No worries we will be back in 2012 for a multiple city tour.
Stay tuned at Shift.PGI.com

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Mon, 14 Nov 2011 06:15:00 -0800 24 Hours In Dubai--A Beautiful Time Lapse Video http://jamesandrews.tv/24-hours-in-dubai-a-beautiful-time-lapse-vide http://jamesandrews.tv/24-hours-in-dubai-a-beautiful-time-lapse-vide

Haven't been to Dubai yet but will be there I'm sure soon. This was a very inspiring video.

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Sun, 13 Nov 2011 05:54:35 -0800 "Inspiring people beget more inspiring people. Inspire on." Shervin Pishevar (@Shervin) http://jamesandrews.tv/inspiring-people-beget-more-inspiring-people http://jamesandrews.tv/inspiring-people-beget-more-inspiring-people Loved this quote from Shervin Pishevar 

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Sun, 13 Nov 2011 05:18:00 -0800 "Wednesday Was A Good Day" Shout To My Friends At Jawbone. This video is Genius. I love my Jambox http://jamesandrews.tv/wednesday-was-a-good-day-shout-to-my-friends http://jamesandrews.tv/wednesday-was-a-good-day-shout-to-my-friends

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Tue, 08 Nov 2011 17:17:22 -0800 Join Me In Atlanta For CNN "Black In America" Screening & Panel #InvestAtlanta #CNN #BlackInAmerica http://jamesandrews.tv/join-me-in-atlanta-for-cnn-black-in-america-s http://jamesandrews.tv/join-me-in-atlanta-for-cnn-black-in-america-s

I'm really excited to be co-hosting #InvestAtlanta, an event of networking, discussion and debut screening of CNN's "Black In America." As a part of a new relationship I'm brewing with 100 Urban EntrepreneursJodi Brockington and I came together with Clyde Anderson, another CNN "face around town" to bring you a great event. 

 

See you there

100ue

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Tue, 01 Nov 2011 16:46:00 -0700 Brass Tokyo | World’s Coolest Shoe Repair Shop | A Continuous Lean. http://jamesandrews.tv/brass-tokyo-worlds-coolest-shoe-repair-shop-a http://jamesandrews.tv/brass-tokyo-worlds-coolest-shoe-repair-shop-a

Brass Tokyo | World’s Coolest Shoe Repair Shop

Oct 31st, 2011 | Categories: Footwear, Tokyo | by Michael Williams

There’s a shoe repair place called Brass in Tokyo like no other I have ever been to. The guys from Red Wing Japan took me there last time I was in country. It are moments like that —when I was first introduced to Brass in person — that make me realize the Japanese can still do ‘Americana’ better than Americans. I could easily see a place like Brass in Portland or Brooklyn or L.A., but I doubt it would have the customer base to actually survive. Maybe I’m wrong though.

Guys come from all parts of Tokyo to have Brass resole their Goodyear welted shoes. In the shop I saw footwear from Alden, Edward Green, Wesco and of course Red Wing; it wasn’t just fine leather bottom shoes it was a mix of brands and styles. That is something that impressed me about Brass. Normally in New York you go to a repair shop and they can redo a pair of Aldens (and know their stuff), but I’ve seen a lot of boots come out of those shops that just look ridiculous. I take my shoes to Mouded Shoe on 39th Street or to VIP on 55th, but never my boots — those get sent back to the OEM. Red Wing has a pretty amazing shoe repair facility in Minnesota (which I have seen a few different times) and Allen Edmonds also has a great repair service which I have also toured. But if I lived anywhere near Brass I would definitely have to try out their service.

To have your boots resoled there doesn’t come cheap. In some cases it can cost more than $300 a pair. Though, when you consider the price of American made leather footwear in Japan (it’s much more expensive over there because of the high import duty) a few hundred dollars isn’t that crazy. Not that I would suggest you pay that in New York.

One other cool thing about Brass is they sell a good selection of re-crafted footwear from many of the fine brands that they specialize in reconditioning. You can see some of the selection in the above photo. While expensive — and all the way in Tokyo — Brass is like no place I have ever seen. If you are in Japan soon, stop by and check it out.

This post originally appeared on the Red Wing Heritage Journal. More photos and info about re-crafting there.

Re-crafted Red Wing Irish Setters

Note the vintage Cat Paw heel

Comments: 17

17 Comments to “Brass Tokyo | World’s Coolest Shoe Repair Shop”

  1. Miguel Ramalhao
    on Oct 31st, 2011
    @ 5:23 PM

    Wow, Anyone who loves a premium pair of shoes love a good repair shop! And this one is the bomb… So cool. I’de love to have a shop like this in my hoje town.

  2. Peter
    on Oct 31st, 2011
    @ 5:24 PM

    What I can’t understand — and I know Japan is a relatively prosperous country — is where young guys get the money to spend $1,500 on a pair of Wescos, then drop $400 more on esoteric customizing.

    And it’s not just limited to Americana — the Japanese go all out in every trend that I’ve seen. Kinda cool, but the fanatical worship of consumer goods in modern Japanese culture is a little creepy. I take it back, not necessarily creepy, but worth investigating.

  3. JRS
    on Oct 31st, 2011
    @ 5:46 PM

    Wow – it’s like the fountain of youth for good boots…

  4. Bandanna Almanac
    on Oct 31st, 2011
    @ 7:07 PM

    On average a single guy in Japan makes a decent salary plus two generous bonuses a year, and with a surplus of single men it’s really no wonder. Plus more often than not they don’t own a car or pay health insurance premiums.

    As for worship of consumer goods I think that’s a worldwide trend. However I’d say Japanese have a better sense of design and taste.

  5. CWW
    on Oct 31st, 2011
    @ 7:51 PM

    Gotta love any shop that extends a “Cordial Welcome”.

  6. Smith & Ratliff
    on Oct 31st, 2011
    @ 8:53 PM

    Amazing. Forget shoe repair, I would pay rent there.

  7. chuck
    on Nov 1st, 2011
    @ 5:58 AM

    The Japanese worship of consumer goods is tied to Shintoism and the belief that every object has a spirit.

  8. chad saville
    on Nov 1st, 2011
    @ 8:34 AM

    what a beautiful place. i miss the old gentleman by the st. marks church in the east village. his cobbler shop had been there for 40 years and smelled like oil, leather, and wood.

  9. SIMON
    on Nov 1st, 2011
    @ 10:34 AM

    @peter ” fanatical worship of consumer goods in modern Japanese culture is a little creepy”

    I do have agree with that statement, the japanese do take trends and fads a little bit tooo far! More so than in western cultures thats for sure!

    I hear its perfectly normal to buy a pair of vintage jeans on layaway in tokyo?

    but yeah their love (or complete obsession) for Americana is definitely a little creepy!

  10. pkyc0
    on Nov 1st, 2011
    @ 10:57 AM

    The japanese ( and other asian cultures) tend to live at home with the their parents until they are married. So while you’re young, everything you earn is disposable

  11. Peter
    on Nov 1st, 2011
    @ 11:36 AM

    Thanks kyco and Bandanna…I suspected it was some combination of all that.

    By “worship of consumer goods,” I probably should have said “fetishization.” And it’s not just Americana — check out any Japanese pop subculture, whether clothes, cars, animation etc. I think it’s cool on one level, but on another I’m not sure it’s healthy.

    I also wonder how much it’s related to the massive societal changes in Japan since the 19th century. Not many other countries have gone from a feudal empire (that defeated Russia in 1905) to a dictatorship (that gave the US a serious scare), to being the subject of an atomic attack, then being occupied by the enemy (that would be the US), then emerging as an industrial powerhouse, THEN, having your economy collapse into deflation.

  12. jiheison
    on Nov 1st, 2011
    @ 2:23 PM

    Peter,

    Japan’s peculiar history certainly plays its part.

    Then again, there are more than 125 million Japanese — more than enough to spawn a large number of fetishists of all stripes. Moreover, all of them are crammed in to a country the size of California, which likely contributes to the sense that these eccentrics are ubiquitous. Nonetheless, I submit that the “norm” in Japan is fairly conventional — so much so that it likely contributes to extremism among the outliers.

    I also note a fetish among many Americans for Japanese fetishists.

  13. David S.
    on Nov 1st, 2011
    @ 3:41 PM

    I can’t tell you how many of your blog posts made me wish I had learned a trade. This one is no exception. Very cool stuff.

  14. Alyssa
    on Nov 1st, 2011
    @ 5:10 PM

    Great find. I have also noticed the Japanese love for Americana. My family owns a small handmade shoe company in Upstate, NY. We have a Japanese buyer who makes his living selling American made shoes and clothing. Here, in the US we’re working on building a solid customer base. In Japan we’re in high demand. It’s interesting for sure.

  15. johnbjones
    on Nov 1st, 2011
    @ 5:49 PM

    speaking of brooklyn shoe repair, Bron Yakov on Degraw Street always did right by me.

  16. Bandanna Almanac
    on Nov 1st, 2011
    @ 6:38 PM

    jiheison, explained it all much better than I would have.

    I live in Japan so I’m always curious about people’s impressions about Japan.

    I really think most misconceptions arise by the lack of direct interaction between Japanese and foreigners. ACL offers his readers a unique insight into Japan with his direct connections through his work. I encourage, if your interested to see more about Japan to read my blog and others.

  17. Ken Marizo
    on Nov 1st, 2011
    @ 7:31 PM

    Yuya Hasegawa shoe shine club, Japan: I know this video has been circulated quite a bit but it just shows the Japanese appreciation for men’s shoes…….. Plus, listening to the audio in the video kind of relaxes me in a strange kind of way:

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Sat, 29 Oct 2011 05:44:24 -0700 He's The DJ....I'm The KeyInfluencer cc:@djjazzyjeff215 http://jamesandrews.tv/hes-the-djim-the-keyinfluencer-ccdjjazzyjeff2 http://jamesandrews.tv/hes-the-djim-the-keyinfluencer-ccdjjazzyjeff2

P156

My friend and "DJ mentor" for 15+ years, The Magnificent DJ Jazzy Jeff. #2012PlanningSession

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Thu, 22 Sep 2011 18:20:00 -0700 REM x #SocialTV--Are You Ready? http://jamesandrews.tv/rem-x-socialtv-are-you-ready http://jamesandrews.tv/rem-x-socialtv-are-you-ready

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Sun, 11 Sep 2011 07:14:00 -0700 Interesting Story About My Favorite Montclair, NJ, Bus Driver & Bus I Was On Sept. 11th http://jamesandrews.tv/interesting-story-about-my-favorite-montclair http://jamesandrews.tv/interesting-story-about-my-favorite-montclair

Before Salvatore Siano, known as Sal, retired, last December, he had driven a bus for the DeCamp bus company, of Montclair, New Jersey, for forty-two years. DeCamp has eight or ten routes, but Sal mostly drove the No. 66 and the No. 33, which wind among West Caldwell and Bloomfield and Clifton and Nutley before joining Route 3 and heading for the Lincoln Tunnel. Unlike some bus drivers and former bus drivers, Sal himself is not buslike but slim and quick, with light-gray hair and eyebrows, and a thin, mobile face. In a region where the most efficient way to commute is by train, the bus can be cozier, more personal. When he drove, Sal reconfigured his bus as his living room, lining the dashboard with toy ducks, chatting over his shoulder with passengers, and sometimes keeping snowballs handy to throw at policemen through the open door. He used to caution children, “I am not a role model!” His travel-guide monologues upon arrival at the Port Authority Bus Terminal—“Welcome to sunny Aruba! Don’t forget your sunblock! Cha-cha-cha!”—won him minor fame.

On the morning of September 11, 2001, Sal was driving a No. 66 bus that began its run at eight-twenty-five. As he headed for the city on Route 3, he saw the smoke rising from downtown. By the time he reached the tunnel, it had been closed, and Sal had received a call from another driver telling him about the first plane. Wedged in heavy traffic, Sal managed to back the bus onto an entrance ramp, turn around, and retrace his route, dropping the passengers at their stops and returning their tickets or cash fares along the way. Six hundred and seventy-nine New Jerseyans, many from towns that Sal drove through, died in the attacks. Afterward, Sal stopped joking around on the bus. When asked why, he grew sad and dispirited, and said that he was too emotionally caught up in the tragedy. Eventually, he began to joke again.

Among his passengers, Sal had many fans. Once, when he pulled up to the Bellevue Plaza stop, in Upper Montclair—this was years ago, before September 11th—he saw such a crowd that he thought he would have to order another bus. But then everyone yelled, “Surprise!” They had been waiting there to give him a party. He had great affection for his riders, and considered ninety-nine per cent of them to be wonderful people. He never asked anyone’s name or occupation, but he learned a lot about his regulars anyway. He believed that he had a skill for picking out the ones who would succeed and, as an example, cites a boy named John Miller, then a Montclair high-school student, who became a well-known journalist and one of the only Americans to interview Osama bin Laden.

Sal lives by himself in a garden apartment in Clifton. In his retirement, he sometimes works for an auto shop, driving to pick up parts. Afternoons, he goes to Brookdale Park, in Montclair, and spends a couple of hours playing tennis or reading the newspapers. Recently, one of his fan-passengers—who can recall many drab morning walks that were improved by the sight of Sal waving to him from the driver’s seat of a passing No. 66—stopped by the park to say hello. Sal was sitting in his car, taking shelter from the rain. A gloomy, apocalyptic quality of the light, maybe caused by the approaching hurricane, led to thoughts about the upcoming anniversary of September 11th. Sal said, “The other day, I was remembering this one passenger from Upper Montclair who always got on at the Norwood Avenue stop, by the public library. After the attacks, I read in the paper—someone must have told me his name—that this man had passed away. He was such a pleasant human being. A man about my height, wore glasses. I had seen him just the week before. The obituary in the Times said this man volunteered to work in homeless shelters, and sometimes slept in them to experience what they were like.” (Here Sal began to cry.) “When I read that, I knew that my instincts about him had been right. I remember him whenever I go by Norwood and the library.”

The passenger’s name was Howard L. Kestenbaum. Along with the names of nearly three thousand other people who died that day, his is inscribed on a granite wall at the edge of the memorial garden in Eagle Rock Reservation, a county park in nearby West Orange, at the top of a ridge with a clear view of lower Manhattan. “He had a wife and daughter, and they are special people, too,” Sal continued. “I still see them around Montclair on a regular basis. Whenever I do, I embrace them and give them a kiss on the cheek.” 

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http://files.posterous.com/user_profile_pics/1093573/5530152644_a7be8f11f2_b.jpg http://posterous.com/users/10z8uN5Ds6R James Andrews The Keyinfluencer James Andrews
Tue, 26 Jul 2011 07:56:00 -0700 "Personal genomics: not just for rich white folks" Article on #Client 23andMe African American Initiative http://jamesandrews.tv/personal-genomics-not-just-for-rich-white-fol http://jamesandrews.tv/personal-genomics-not-just-for-rich-white-fol

This morning personal genomics company 23andMe launched an initiative designed to shift the balance in favour of participation of one non-European minority both in personal genomics and genetic research. The Roots into the Future project will recruit 10,000 African-Americans by offering volunteers free genetic testing, and full access to the results of their tests. The recruits will also be given an opportunity to participate in the same types of genetic research the company performs on its existing customers: basically, answering survey questions that can then be linked with genetic data to explore potential associations.

This is an important announcement. Personal genomics has, since its inception, been predominantly a game played by white people. An illustration: recent numbers on the ethnic breakdown of 23andMe customers indicate that of the ~81,500 customers with self-reported ancestry in the company’s database a whopping 74.7% are primarily of European descent. African-Americans are particularly poorly represented in the customer base, comprising just 1.2% (compared to 12.6% of the total US population).

That’s not to say that the personal genomics companies haven’t already made efforts to broaden the genetic diversity of their customer base. 23andMe’s founders appeared on Oprah in November 2008, and the company has made a rather determined effort to avoid too much pallid skin on its front page. Here’s a screenshot from the company’s home page in May last year (courtesy of the Wayback Machine):

Still, that 75% European number is a troubling one. A genetic revolution in healthcare is approaching – or at least that is the hope – and those who have received an education in the SNPs and haplotypes of modern genomics will be better-placed to take advantage. Right now, one of the best ways to gain insight into modern genetics is to dig deep into your own DNA; it would be a shame if such opportunities were only taken up by a select few with defective pigmentation genes.

Sadly, as was noted in a recent Nature opinion piece by Carlos Bustamante and colleagues, the dominance of European genomes is found in academic research facilities as well as the storage warehouses of personal genomics companies. A 2009 review found that just 4% of the participants in published genome-wide association studies had non-European ancestry. That’s not only a tragedy from a social perspective – it also represents missed scientific opportunities.

African-American genomics presents both challenges and opportunities. Finding the genetic basis of disease in such admixed populations is more complicated than in relatively genetically homogeneous European cohorts, requiring extra care to avoid false positives due to population structure. The greater genetic diversity found in African genomes can also be poorly captured in some places by standard genotyping arrays. However, there are positives as well: the decreased linkage disequilibrium in African genomes means that analyses in this population can zoom in on the real causal variants more effectively than in European genomes, where the signal of association tends to be spread out over much larger regions.

23andMe is rapidly (and fairly successfully) rebranding itself as primarily a research company rather than a consumer genetics provider. By leveraging its customer database of both genetic and trait information (obtained from online surveys) the company has demonstrated that it can not only robustly replicate known gene-trait associations, but also discover completely novel associations. 23andMe recently published two completely new variants associated with Parkinson’s disease, following on the heels of its 2010 publication of seven new variants associated with non-disease traits.

23andMe’s ability to generate novel genetic associations will rely on continuing to explore niches largely neglected by mainstream academia. That means focusing both on traits considered “frivolous” (such as the ability to smell asparagus in urine), and on targeting populations that have not been well-recruited by other research groups. The company’s new focus on African-Americans will complement existing campaigns targeting specific diseases (such as Parkinson’s and sarcoma).

Does this herald a wave of additional campaigns by 23andMe targeted at other under-represented minorities? Maybe, maybe not – in an email, research director Joanna Mountain told me that the company wanted to focus on African-Americans for the moment, but would “continue to review the possibility of expanding this project to include other communities.” She also confirmed that the company would be using its standard v3 chip for these analyses, rather than including additional content designed to capture African haplotypes more effectively. This may be a mistake, but not an irreversible one – the company can always go back to the DNA samples of customers (at least those who consent for their sample to be stored) for further testing. Finally, she gave a sense of the research priorities here: the company’s “initial focus is on replicating results from previous genome wide association studies conducted in other populations, but we will also look for ways to improve ancestry interpretations of the data.”

Overall this seems like a commendable initiative. It seems likely that – assuming the company achieves its recruitment goals – they will be able to contribute substantially to our understanding of disease genetics in a politically and medically important non-European population.

Excited to announce a project Social People is working on for client 23andMe. Looking forward to marketing this amazing service (I'm a user) to African Americans

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http://files.posterous.com/user_profile_pics/1093573/5530152644_a7be8f11f2_b.jpg http://posterous.com/users/10z8uN5Ds6R James Andrews The Keyinfluencer James Andrews